The short answer
If you have stock recovery and have not modified any system files, you will be able to OTA without a problem. Did it myself from 4.4.2 to 4.4.3.
The long answer
Here is how updating works:
The updater has a list of files that are going to be modified by the update. It first calculates the checksum of every file that is going to be modified and compares it to the cheksum it has on a list. If there is a checksum mismatch, the update process is aborted. If all the checksums agree, the updater starts patching the files.
Now, since the updater doesnīt expect you to have xposed and supersu on your system partition, it doesnīt look for them and it does not care about them - it just patches the files on the list. Thatīs all.