I don't know exactly, but it seems like it is just to do with the specific settings (inside the default settings section). Using the driver is fine, but any of the options being ticked has the ability to make some applications go awry depending on the device. Those options, i assume, are only meant to be used when you want to use a specific app that requires or benefits from them.
Also, i've noticed great improvements in ES File Explorer scrolling. It would lag a fair bit scrolling through long folders, but now it's nice and smooth.
Device: Galaxy Nexus i9250
Previously: Nexus S i9023