We're having the same issue with JuiceDefender and our Amaze 4G. The radio will not be enabled after the waking the phone, and I have to toggle it off/on manually to get it to reconnect. I thought JuiceDefender was working great on my wife's phone, as she had 70% battery left after almost an entire day. I then noticed that the radio was not turned on (we were nowhere near our home/Wifi), and she claimed that she was experiencing a massive delay in getting messages (email/MMS). I tried tweaking all sorts of settings in JuiceDefender (it's overwhelming to try and determine the impact of changing any of the settings), but no luck. The problem, from what I can tell, appears to be when switching from Wifi to 4G, and vice versa. At this point I've disabled JuiceDefender (I have the Ultimate version), and have relied on disabling AutoSync (still unclear on what this really does) to help save some battery. I've also ordered the Mugen 1950mAh extended battery. It just got to the point where JuiceDefender was interfering with the functionality of the phone, so I had to disable it. I got the most recent HTC software update a few weeks ago, but it didn't help much in the battery drain area.