Prompt USB Debugging etc

Hi close to get crazy.
If have a ONE X+ with CM10.1 and cannot connect the Phone with USB.
Allways the fastboot massage - Device offline- After installing new Drivers, phone asked me to allow USB Debuging one time,
but never again. Two days ago a reboot with fastboot worked. I tried a other Computer... ADB Network is ????
On my Computer i have one old driver i cannot deinstall!!!!!
Are anybody out ther with help for me????