I've unlocked all 4 DNA's that I've had on a Windows 8.0 - 64 bit machine.
First one with Jcase's original exploit. Second with Supercid and HTCDev unlock. Third and fourth with Moonshine.
If you're on Windows 8.0, downloading PDANet will install the correct drivers.
Windows 8.1 however, broke the Fastboot drivers.
Hope this helps
As always, have fun.