Default [Q] Factory reset a rooted, wifi mod verizon - cause reset issue?

May need to reset to see if bootloop issue is a hardware problem as last resort
Verizon 4.2.2 11A stock, build JDQ39B, rooted, wifi tether mod, OTA been blocked by Titanium for months, no custom recoveries or rom.
Can I do a factory reset and wipe with the phone in the above condition or will the root and mod cause an issue?