Most any (good) root app that'll let you uninstall system apps should also let you freeze them (as well as back them up). Titanium Backup is one of the best and most popular, Rom Toolbox Pro is great too. Before uninstalling anything, freeze it first, and use the phone for a while to see if any problems arise. If not, BACK IT UP before removing it. You can store your back-ups on your SD card, or save them to your computer. This way you can free up the space on your phone, but you can still put it back on your phone if you need to (for an OTA update or warranty service, for example).
Clean Master, besides being a great RAM booster and junk file cleaner, also has an app manager that (with root access) can do backups and uninstalls, but also sorts the apps into what's safe to uninstall and what shouldn't be uninstalled. Use this as a guide, but follow the steps above as well (you'll still need Titanium or Rom Toolbox or similar; pay the $6 or $8 or whatever it costs - it's worth it).
Relax, go nutz!