Default [Q] Buttons not responding

I'm having the following issues with my HTC Evo 3D,

1) All the buttons on the lower part of the phone are not responding (Home, Menu, Back & Search Buttons)

I've tried to recalibrate the G-sensor, keyboard but the situation still the same.

Would like to seek dome help to troubleshoot the problem as I'm hardcore HTC supporter. Currently using HTC One M7 while the Evo 3D as my 2nd phone.