I bought a DC cig lighter USB plug, gutted it and used the inerds to connect to 12v and allow my wireless charger (or any charger) to connect to. The cig lighter is already a fused circuit. If you are running a wire from the battery, then fuse it.
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There are just too many variables for this to answer. You aren't trying to keep the email radio are you? If so, why? The tablet can do radio stations, stored music, movies, Netflix, YouTube, bluetooth calls, ect. Again, I never understood the need for some people to want to keep the OEM head unit.
How many door speakers do you have? Are you going to upgrade them to aftermarket? Any subs? If so, how many?