I tend to change only the build.prop file. Sometimes things will move around on the desktop but I haven't used the tw launcher in some time simply because I like Nova. If things aren't looking the way you like try upping the dpi. I use 320 but I personally think 360 is the best compromise.
Also some apps may not like the dpi change. When this happens I suggest using xposed module that changes dpi on a per app basis and increasing dpi until you like the look.
It's a lot of trial and error to get a setup you will be happy with.
Hope this helps.
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