It's a mystery to me why you guys are seeing speed-ups by using more aggressive lowmemorykiller settings. I've tried that, and it didn't help.
My biggest complaint about Android has always been the time required to switch between apps. Knowing that Android will leave background apps in memory so long as there is sufficient free memory, I tried these less aggressive settings in AutoKiller:
5,6,7,8,22,24 (MB)
instead of the default
6,8,16,20,22,24
This gives me 12 more MB for background apps, which has made a big difference: now I can fit one or two more big background apps in memory, so that switching between them is a lot faster. That really helps for using the Browser and Opera Mini.
There is really no such thing as optimal lowmemorykiller settings. Performance for any given settings will always be a function of which apps you use and how you use your phone. Everything is a trade-off: Aggressive settings favor the foreground app, though possibly forcing some background apps to unload and reload themselves more often, which impacts the foreground app. Less aggressive settings favor background apps, and speed up app switching.
On a related note, I've started a thread at Howardforums with a lot of info on how to get the memory hogs out of your system. This has sped up my phone more than anything else.
Speed up Android by reducing application memory usage