I used to temp unroot when using sky go and restore root afterwards. All this can be done without a reboot.
Use hidemyroot or voodoo ota rootkeeper to make a copy of the su binary, unroot device, uninstall superuser app, force close sky go if its running and then reopen.
I wonder if you could used the multi user function of 4.2.2 to run sky go under another user
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