I'm going to provide a somewhat tenuous dissenting opinion. I'm coming from a Gnex, and picked up a DNA last night, which I'm considering switching to full time. After 24 hours with it, I'm quite pleased by the hardware, and utterly horrified by the software.
Sense is, in my opinion, complete and utter crap. There's no other way for me to put it, I hate almost everything about it. It's as if they locked several caffeinated adolescent boys in a room and told them to design a skin while watching episodes of Transformers. Viper is making it somewhat tolerable, but man am I anxiously awaiting AOSP. That said... the hardware, oh the hardware. The screen is simply gorgeous, and the battery life is easily twice what I got with my Gnex. In addition, I have 2-3 bars of 4G at work where I had 0-1 bars of 3G before.
The hardware advantages this has over the Gnex are sufficient to keep me from selling this thing in the hopes that AOSP is coming soon. If anyone reading is on the fence, and isn't sure how they'll feel about Sense, I'd advise waiting for prices to come down. I'll probably still pop my SIM into the Gnex here and there to experience Android as it was intended to be.