OK...I'll answer the first part of your question:-
I always wipe when moving from an AOSP based rom to Samsung/TW based rom or vice versa. I also tend to wipe when moving to a completely different rom, even if it's the same base (I just like how the phone operates after a clean install when switching roms), though whether you do this is up to you (and depends on what the dev of the rom in question says; if he says wipe, you do it). When flashing a different build of the same rom, I normally only wipe if there's been a change in Android versions (from 4.2 to 4.3, as an example). If it's the same rom/same Android version, I tend to do a dirty flash & just wipe cache/Dalvik.
As I mentioned above, the caveat over all of what I've said is the flashing instructions for a particular rom/build of a particular rom, if the dev says wipe in the instructions, you do it. Always. If the dev says a wipe isn't necessary, then you don't need to unless you want to/or run into problems.
Your 2nd question re: toggles on that theme will have to be answered by someone else/someone who uses the rom.
Edit - Also, before you flash any rom, even a new build of your current rom or nightly (or any mod for that matter), do a nandroid backup. Always. That way, if you do run into problems after flashing a new build, you can always restore your nandroid/go back to the previous build & try the flash again/whatever.
If it's important enough to cause you grief if it's lost, back it up. No excuses
Trolling for thanks is lame
Does Samsung's auto-brightness implementation crap drive you to self-harm ? A solution !
Most retarded thread on XDA in 2013