That's what I'm running now. No issues.
Personally I'd do it with adb for when something goes wrong you know how to fix it. When I unlocked and flashed recovery on my phone, everything wiped, even the stock rom was gone. Luckily I learned adb with my galaxy nexus and was able to restore the factory images with fastboot (minus recovery) and start over.
Also don't use the newest twrp. It was wiping my baseband and I reverted to the last version through fastboot to get it working.
Sent from my Nexus 4