You can remove the basic bloat that comes with every android, like stocks, news, gtalk (in case you don't use it), books, facebook (everything from FB if you don't use it, but I'm unsure if this affects the phone somehow; it shouldn't though), friend stream, news&weather (I don't know how this work, never used it), peep. I think that should cover almost everything but I am not 100% positive about this; I will s-off my phone this week and root it. Only afterwards I can confirm about which apps from above are 100% safe to remove.
If anyone tried any of the above it would be nice to know which ones are safe before we perform the trial and error with these.
P.S.: You can remove the apps above only if you have s-off and a rooted phone though; unfortunately you will have to wait for HTC to unlock the bootloader or find someone with an xtc clip.