I have the galaxy Note and it fits fine in the pocket of my business pants. It does not in anyway stick out nor is it uncomfortable. I barely notice it is there, and on a few occasions had to slap my hand on my thigh to ensure that it is still in my pocket due to it's thinness.
At 170g+, it is a mere 30g ( 1 oz) heavier than a iPhone 4S, so how heavy can it be ?
The Note is about the width of my palm, shorter than my hand and way thinner. So if you can stick you hands into your pocket, you can most certainly fit your Note into your pocket.
Finally, to share my experience, I went on a 2 week vacation recently and did not bring my laptop ( I usually do ). Instead, I relied entirely on my Note to surf the web for destination info and attractions, book hotels and tickets for my next destination, download maps, etc etc, all the stuff I used to do on my laptop.
The 5.3" screen made all this a snap, and not once did I miss my laptop. Imagine doing all that without lugging 4 lbs of laptop and laptop charger. A travel-light advocate's dream device.
Plus the GPS is super sensitive and I get GPS locks very fast. The only complaint I have is that, due to the huge screen, it's hard to use it with only 1 hand ( for me, that is). Other than this, this phone is a keeper.