AOSP will always be the best, but Sense doesn't suck. I'd take Sense over almost any other Skinned UI, TW and "Blur" really suck and LG's UI is just sad. So I can deal with Sense, but nothing's faster or smoother than pure AOSP.
Current Phones: CDMA Galaxy Nexus (Toro)
Roms: Carbon, Xperience, AOKP, Liquid Smooth (most recent)
Kernel: Lean Kernel, AK Cylon or Franco (most recent)
Radios: FK01 / FK02 (4.2.2)
HTC Rezound (Backup Phone)
Droid 2 / 3
HTC Droid Incredible