The main piece you care about in your Profile is your 3g login. If you are getting 3g, then you don't need to worry about it. The recent PRLs have often reduced the amount of 3g roaming you have, so not updating that might be a bonus. Though with NV there might be some improvements (then again, there might not, because Sprint feels less need to roam with their improved infrastructure)
Now if you should for some reason perform a ##786# or ##72786# reset, then you would need update profile to work (and also hands free activation) because doing a manual provision can be a pain for the 3g portion.