Default [Q] Factory Reset Q's

My tpt has been acting a little flaky. So, I am thinking a factory reset is in order. But, I don't want to have to set everything up again from scratch. So, I was wondering what would be the best way to backup apps and homescreen config data?

I've done a Titanium Backup of all user apps and system data. But, I'm worried that restoring system data might bring back whatever is causing my current flakiness.

Also, if the factory reset destroys all data on the TPT, how do I save the Titanium data for restoration? Can I copy the Titanium Backup folder to an SD or PC, and restore from there after reset?

Should I temporarily unroot using RK before reset?

I assume I will have to download and re-install RK, TB, and SU after reset. I'm just worried that if my current issue of the Play Store not being able to DL apps isn't fixed by the reset, I'll be screwed.

TIA