My Chrome beta works quite well overall on 4.2.1 and now on 4.2.2.
However it struggles badly with the news Australian google news site.
Freezes after every 2nd or 3rd action.
Wonder if this is very website (or HTMLfeautre) specific and depending on your browsing habbit you have 0 to many problems.
Nexus 4, Stock 4.2.2 unlocked, reflashed on Vodafone Australia.
Google (Samsung) Nexus 10 16 GB, JB 4.2.2 rooted using Wug's Nexus Root Toolkit v1.6.3.
HTC One X Stock
Samsung HD Icon/i8910
HTC 3600/Dopod 810
and a dodgy Zenithink ICS Tablet