Titanium backup is to back up apps and data or settings that you like. I wouldn't recommend restoring a backup to a different ROM. For example let's say I'm on wicked right now and I made a backup with titanium backup. It wouldn't be wise to move to darthstalker and restore it. It will most likely conflict with other Roms. As long as you keep track of what ROM the backup goes to you should be fine.
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