Originally Posted by gigadigit
It was happening to me all the time. I had to get a screen protector and haven't happened since.
Very good "solution" to what should be an obvious problem. The Nook Color has a *capacitive* touch-screen. If you get "junk/gunk" on the screen, it's gonna cause you issues. I find this to be the case while holding my NC and playing Flight Director for a while. The issue: My hands become sweaty and as a result of the slight film of sweat/oil on the screen, the NC's ability to measure the capacitive changes on the screen (and react appropriately to them) is compromised.
Keep your screen clean and you won't have this issue.
Note: after you wipe the screen down (damp cloth, etc), you will need to click the power button and go the lock screen and then back into the NC before it works right directly after cleaning the screen. The dampness of the cleaning cloth throws up the calibration enough to cause very strange things. My experience with "correcting" this issue tells me that in some way, the NC is recalibrating itself when you go to the lock screen.