I've been using LauncherPro almost since the first version was released, when I was using a Sprint Hero. It just keeps getting better and better with every upgrade. I haven't looked at the Sense UI on my phone in at least a week. And that was just because I was comparing the flip clock/weather widget from Fancy Widgets with the HTC flip clock/weather widget, to see the differences. They are almost identical, pixel for pixel.
Also, to get more of a sense ui feel out of the launcher, you can set up 7 home screens, and download smooth calendar from the market. It looks very similar to the 1 x 4 calendar widget from HTC.
One of my favorite features of the launcherpro is the 3d app drawer. Also, the row of icons at the bottom, that you can configure however you want.
And it's nice with the huge screen, to have 5 rows of icons on the home pages. I turned off auto-orientation, as 5 rows of icons looks like crap in landscape.