Since you mention the Droid, I assume you're in the US. Fortunately, the Droid has even less Moto-branded crapware than the Milestone. You won't get Motonav (you get stock Google Navigation instead), the Phone Portal, or any of the Milestone replacement apps (gallery, music player)—all of this stuff is stock Android on the Droid.
Basically the only uninstallable preloaded crap is Car Home (which is actually much better in 2.2), the Amazon MP3 Store, and Verizon Visual Voicemail. Like the others said, no Motoblur or anything like that.
The Droid also has an unlocked bootloader, so you CAN do custom ROMs with it. Sorry to you Milestone users