I don't have experience with your specific case, but when it comes to removing touchwiz from system/app I have noticed problems. For one, when I select Airplane mode, phone lags and I get a force close error. Another, I experience longer (not considerably longer, but still longer) boot times. Tried various things such as factory resets, flashing touchwiz-less systems, but still got these error.s Both issues remedied by putting touchwiz back in system/app.
So yea, not directly answering your specific case, just saying it's possible since removing touchwiz seems to cause problems for myself.