Launcher Pro is fast but its application drawer is very limited (it basically dumps a huge scrolling list of icons). Touchwiz is reasonably nice, but managing hundreds of application icons remains hard, despite the "move icon" feature in the application drawer. ADW.Launcher however, provides separate "groups" / "catalogs" panes to divide the application drawer into several distinct buckets of smaller size, which makes it a lot easier to find applications. I just hate browsing endless list of alphabetically-ordered icons
As for QuickDesk, it has some potential, but it is somewhat locked to portrait mode on my Galaxy Tab
I am using it anyway as it plays nice with ADW.Launcher (the Home button gets hacked to support single/double tap and launch each of them individually).