Yep. Usually a cache/dalvik wipe is all that is needed for nighties after the first initial factory reset and format install. Most of the time that isn't even really needed but it's an excellent habit to keep anyway because the one time you don't wipe is when your phone decides it's time to divide by zero just to mess with you.
Edit: I should also add. If you're new to the nightlies flashing. I'd read this thread before flashing a new nightly. Nightlies aren't guaranteed to work. May even be broken. So to avoid finding it out the hard way and having to flash back to an old nightly see what the early flashers report back and see if they give the `all clear'.
