Well each time I flash a ROM, I wipe Davlik, format System, Data, then Cache. Then wipe all user data/factory reset. I'm using RCMix (obviously), and the GPS was working fine before. I tried the new Android Revolution and no GPS lock either, so I'm fairly sure it isn't the ROMs.
Haven't tried a wipe script however.
Just so we're clear for other reading the thread, your GPS stopped functioning prior to trying this patch. You tried it as an attempt to get your GPS operational once again...
If you're somewhat brave and the phone's out of warranty, check out my second post on the thread. There are known hardware issues on some DHD and Inspire 4G phones. If you have some sturdy hands, that fix worked for someone else with a hardware problem who tried my patch before determining it to be so.