It shouldn't mess with sensitivity. I can't promise that since the case isn't out yet, but I've had otterboxes on every phone I've had and I always put a regular screen protector on underneath the otterbox anyway and I've never had a problem. I took the plastic off of one of my old otterboxes and laid it down on top of the screen of my Note and tried using the pen and it was super smooth just as if there were no screen protector on at all. I have a zagg shield on it now and I can barely use the pen for anything so I can't wait to get my otterbox.
I pre-ordered it from here. It was a good price, and says 4/20/12 on the release date, although it is now the 22nd and I have yet to receive any tracking information, and it still says pre-order. I smell fish.
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