CorruptedSanity,
I used GO Launcher for almost a year on my Desire HD, but when I moved to the Note, it was not as smooth as ADW Launcher EX.
Go Launcher has amazing features sur as dockbar icon swipe to launch actions, integrated plugins and so on that you need to find replacement for when using ADW Launcher but if you stick with a laggy launcher (as I use a lot of scrolling widgets), it ruins everything.
So now, with no cache set in config, I can swear that ADW Launcher EX is probably the best launcher for Note in terms of smoothness (and I tried a lot, including 360 Launcher, before writing that).