Flash with ClockworkMod 3+
You will need to add your own busybox should you wish to use apps such as Titanium Backup. That can be done quite easily via the Market.
I personally don't like HTC Sense , but I wanted to try the latest 2.50 base. So I though I'd share.
I don't envisage updating this ROM with features as I just want to try Stock HTC Sense. If it contains bugs then HTC put them there.