I did try it on my NC, running CM7 Nightly 144, with the kernel OCd at 1.2GHz and I daresay it did made a lot of difference. It made my Nook noticeably more snappy, and reduced the lags I've been getting whenever I multitask.
When I ran the script the first time and rebooted the device, the 'SuperCharged' state did not persist. I later on figured out that it was because I had the app called AutoKiller Memory Optimizer running. I uninstalled that app and ran the script once more, rebooting the NC, and I found out that that did the trick: the supercharged state DID persist after the reboot.
It's really great because I strongly believe that it did made my NC a lot faster and more responsive. You might wanna give it a go too.
Here's that link again: http://forum.xda-developers.com/showthread.php?t=991276
Throw me some questions about it--I'd be glad to help.