Funny. Going back to CM11S didn't fix it for me. And, as I previously said, I've been on X number of Android 5.x.x ROMs before this issue appeared.It is indeed a ROM (or Kernel or CM?) issue. I've used the early und unofficial builds of CM12.1 (well at least Lollipop 5.1) and had no issues at all. The opposite was the case: everything worked and I percieved the system like 10 times faster than CM11S.
In the last 2 days I installed and tested the old unofficial builds and everything worked again (especially the ones before the 31st of march).
Then again I also tested the lastet CM11s build and at least the touchscreen worked million times better than the one of the latest CM12.1 builds. I updated then to CM12s and for me it is the best solution, because it works like it should.
I'll wait for the official COS versions. I'm a former Nexus user (from the One to the 5 I had everything except the S) and its horrible that the current betas are this broken.
I think I'll flash CM11S and update to CM12S to test that myself.