it's kind of an impossible question. Everyone's hands are different. I can palm a basketball with long fingers on a comparatively smaller palm, so I can navigate damn near any phone short of 6" single-handedly with ease. And even then, the Huawei Nexus 6P I can use one-handed fairly easily. But the Moto Nexus 6, not so much. But I still do prefer the smaller phones for pocket comfort, as I dislike belt clips and holsters. So I chose the S7 over the Edge. And I honestly LOVE it. No problems whatsoever with the size in my hand or pocket. I haven't put a case on it yet. Honestly, I don't want to, no for the sake of size, I just don't wanna cover this beauty up. But I will be buying a thin one for it shortly. Likely before the end of the day honestly