Here we go again...
This is driving me nuts...

Using my Nexus 7 the past few days, the music lags/distortions slowly reappeared.
I tried to pay attention when they happen. So far I noticed most of them while:
Opening a new tab in Chrome, switching between apps (fullscreen animation), having heavy disk I/O (i.e. installing/uninstalling apps). But sometimes they just appear out of nowhere, even when not doing anything at all, though.
Here's a collection of things I tried so far to eliminate the issue:
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Cache partition wipe: like mentioned helped at first but soon the issue reappeared.
I also wiped the cache partition again yesterday and the issue actually got worse afterwards this time...
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Keeping RAM clean: tried numerous apps to close unnecessary background apps and free RAM. Seems to reduce the issue a bit.
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Turning off 'click' sounds: in the sound menu there's a toggle for sounds when touching the screen (i.e. clicking on an element within an app). Turning it off actually helped a bit, because the music lags at least won't happen at times when the click sound would be played, anymore. (Which happened often to me before)
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Using Poweramp: this music player app allows you to increase the audio engine's buffer size and process priority. I tried tweaking these settings to no avail. It seemed fine at first but the lags reappeared quickly despite having increased process priority and buffer size. Other third-party players I tried have the same lag issue as well.
I looked around the net and also through the Android bug tracker. Despite of this thread I rarely found any related report so I begin to wonder if other Nexus 7 owners aren't noticing or simply ignoring this issue or if my device is faulty.
I somehow doubt the latter though, because everything else is mostly completely smooth including video playback, Android GUI, scrolling in Chrome etc.
To me it seems more like a multithreading issue (which would be ridiculous having a quad-core processor) or a memory/disk access bottleneck.