I tried this, but i have the S4 active (I9295), and it's little different
1. install "root Explorer"
2.Go to "System"
3. Go to "Usr"
4.Go to "KeyLayout
5. go to "gpio-keys.kl" with Longpress and choose Open in Text Editor, and choose Yes
It's the line with 172 as the key number listed..
172 HOME WAKE
I removed the HOME (not POWER like the video said) and added the "_DROPPED" to "WAKE" so the line looks like:
172 WAKE_DROPPED
Go back and save
Reboot, and your home button works only if you have your screen on, and won't turn screen on if pushed
First attachement is before change,
second is after change
The Other way is Download and install Wanam Xposed,
http://forum.xda-developers.com/showthread.php?t=2383484
See Third Screenshot
This is easier, and if you installed it you have way more options to customise your S4 Active
Have Fun